Selected Publications

2024

A roadmap to precision treatments for familial pulmonary fibrosis.

Killian Hurley, Mari Ozaki, Quentin Philippot, Galvin Liam, David Crosby, Kirwan Mary, Deporah R. Gill, Konstantinos-Dionysios Alysandratos, Gisli Jenkins, Matthias Griese, Nadia Nathan, Raphael Borie, COST Open-ILD Group Management Committee

EBioMedicine. 2024 Jun:104: 105135. PMID: 38718684.

An evaluation of an open access iPSC training course: “How to model interstitial lung disease using patient-derived iPSCs”.

Anja Schweikert, Sarah Kenny, Irene Oglesby, Arlene Glasgow, Chiara de Santi, Ingrid Gensch, Nico Lachmann, Tifenn Desroziers, Camille Fletcher, Deborah Snijders, Nadia Nathan, Killian Hurley, and COST Open-ILD Group Management Committee.

Stem Cell Res Ther. 2023 Dec 20;14(1):377. doi: 10.1186/s13287-023-03598-9. PMID: 38124115.

2023

Sexual Dimorphism in Interstitial Lung Disease.

Ozaki M, Glasgow A, Oglesby IK, Ng WL, Kelly S, Greene CM, Durcan L, Hurley K.

Biomedicines. 2022 Nov 24;10(12):3030. doi: 10.3390/biomedicines10123030. PMID: 36551792; PMCID: PMC9775147.

2022

A multimodal iPSC platform for cystic fibrosis drug testing.

Berical A, Lee RE, Lu J, Beermann ML, Le Suer JA, Mithal A, Thomas D, Ranallo N, Peasley M, Stuffer A, Bukis K, Seymour R, Harrington J, Coote K, Valley H, Hurley K, McNally P, Mostoslavsky G, Mahoney J, Randell SH, Hawkins FJ.

Nat Commun. 2022 Jul 29;13(1):4270. doi: 10.1038/s41467-022-31854-8. PMID: 35906215; PMCID: PMC9338271.

CoSpar identifies early cell fate biases from single-cell transcriptomic and lineage information.

Wang SW, Herriges MJ, Hurley K, Kotton DN, Klein AM.

Nat Biotechnol. 2022 Jul;40(7):1066-1074. doi: 10.1038/s41587-022-01209-1. Epub 2022 Feb 21. PMID: 35190690.

Short-term intermittent cigarette smoke exposure enhances alveolar type 2 cell stemness via fatty acid oxidation.

Ozaki M, Irie H, Chubachi S, Hegab AE, Tsutsumi A, Kameyama N, Sakurai K, Nakayama S, Kagawa S, Wada S, Ishii M, Betsuyaka T, Fukunaga K.

Respir Res. 2022 Mar 2;23(1):41 doi: 10.1186/s12931-022-01948-4

Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters.

Sun YL, Hurley K, Villacorta-Martin C, Huang J, Hinds A, Gopalan K, Caballero IS, Russo SJ, Kitzmiller JA, Whitsett JA, Beers MF, Kotton DN.

Am J Respir Cell Mol Biol. 2021 Oct;65(4):442-460. doi: 10.1165/rcmb.2020-0259OC. PMID: 34101541; PMCID: PMC8525201.

2021

Effect of High Fat Diet on the Severity and Repair of Lung Fibrosis in Mice.

Ozaki M, Hegab AE, Kagawa S, Fukunaga K.

Stem Cells Dev. 2021 Sep 15;30(18):908-921 doi: 10.1098/scd.2021.0050

Increased focus on non-animal models for COVID-19 and non-COVID lung research.

Gribaldo L, Hurley K, Hiemstra P, Greene C.

Eur Respir J. 2021 Jan 14;57(1):2004267. doi: 10.1183/13993003.04267-2020. PMID: 33446578; PMCID: PMC7806967.

Lung organoids and other preclinical models of pulmonary fibrosis.

I K Oglesby, A Schweikert, B Fox, C Redmond, S C Donnelly, K Hurley.

QJM: An International Journal of Medicine, Volume 114, Issue 3, March 2021, Pages 167–173.

A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells.

Kaserman JE, Hurley K, Dodge M, Villacorta-Martin C, Vedaie M, Jean JC, Liberti DC, James MF, Higgins MI, Lee NJ, Washko GR, San Jose Estepar R, Teckman J, Kotton DN, Wilson AA.

Stem Cell Reports. 2020 Jul 14;15(1):242-255. doi: 10.1016/j.stemcr.2020.06.006. Epub 2020 Jul 2. PMID: 32619491; PMCID: PMC7363960.

2020

Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study.

Drake TM, ..., Hurley K, J… Jenkins RG; ISARIC4C Investigators.

Am J Respir Crit Care Med. 2020 Dec 15;202(12):1656-1665. doi: 10.1164/rccm.202007-2794OC. PMID: 33007173; PMCID: PMC7737581.

Optimizing the in vitro colony-forming assay for more efficient delineation of the interaction between lung epithelial stem cells and their niche.

Ozaki M, Kagawa S, Ishii M, Hegab AE.

J Stem Cell Reagen Med. 2020 Dec 11:16(2):50-62 doi: 10.46582/jsrm.1602009

Exposure to Cigarette Smoke Enhances the Stemness of Alveolar Type 2 Cells.

Ozaki M, Tsutsumi A, Chubachi S, Irie H, Sato M, Kameyama N, Sasaki M, Ishii M, Hegab AE, Betsuyaku T, Fukunaga K.

Am J Respir Cell Mol Biol. 2020 Sep:63 (3):293-305 doi: 10.1165/rcmb.2019-0188OC

Precise Targeting of miRNA Sites Restores CFTR Activity in CF Bronchial Epithelial Cells.

De Santi C, Fernández Fernández E, Gaul R, Vencken S, Glasgow A, Oglesby IK, Hurley K, Hawkins F, Mitash N, Mu F, Raoof R, Henshall DC, Cutrona MB, Simpson JC, Harvey BJ, Linnane B, McNally P, Cryan SA, MacLoughlin R, Swiatecka-Urban A, Greene CM.

Mol Ther. 2020 Apr 8;28(4):1190-1199. doi: 10.1016/j.ymthe.2020.02.001. Epub 2020 Feb 6. PMID: 32059764; PMCID: PMC7132615.

Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows during Differentiation of Human PSC-Derived Distal Lung Progenitors.

Hurley K, Ding J, Villacorta-Martin C, Herriges MJ, Jacob A, Vedaie M, Alysandratos KD, Sun YL, Lin C, Werder RB, Huang J, Wilson AA, Mithal A, Mostoslavsky G, Oglesby I, Caballero IS, Guttentag SH, Ahangari F, Kaminski N, Rodriguez-Fraticelli A, Camargo F, Bar-Joseph Z, Kotton DN. Cell Stem Cell. 2020 Apr 2;26(4):593-608.e8. doi: 10.1016/j.stem.2019.12.009. Epub 2020 Jan 30. PMID: 32004478; PMCID: PMC7469703.